The single biggest performance lever for a globally-distributed system is reducing the network distance between users and the data they read. Multi-region read replication maintains read-only replicas in each region where users live, with writes flowing to a primary and reads served from the geographically nearest replica. This guide covers when the pattern is the right answer, the read-after-write consistency strategies that determine whether the application can tolerate replication lag, the database technologies (Postgres logical replication, Aurora Global, DynamoDB Global Tables, CockroachDB, Spanner), production configuration with Postgres, and the operational discipline that prevents subtle consistency bugs.